At age four, Zabou played in one of the episodes of the TV show Thierry la Fronde alongside her father, Jean-Claude Deret. Zabou studied cinema, modern Greek and English for her bachelor’s degree and attended the Simon course. She was a television host at “Recré A2” in the 80’s and made her film debut in 1982. In a short time, she became a well-known actress for her roles in comedies (Banzaï, The Beauf, Promotion Sofa). In the 90s, she worked with filmmakers like Diane Kurys (La Baule-les-Pins, 1990), Coline Serreau (The Crisis, 1992), the Jaoui / Bacri tandem in Kitchen and Dependency in 1993, Philippe Lioret (Correspondance Required, 1997) and Pierre Jolivet (My Small Company, 1999).
In 2001 she directed her first feature film, Beautiful Memories, with Bernard Campan and Isabelle Carré. The film was awarded 3 Césars including Best First Feature Film. This was followed in 2006 with The Man of My Life and in 2009 Je L’Aimais. During this decade, Zabou Breitman acted in the films of Michel Deville (Almost Peaceful, 2002), Gilles Lellouche (Narco, 2004) and Rémi Bezançon (The First Day of the Rest of Your Life, 2008).
She acted under the direction of Pierre Schoeller, The Minister starring Olivier Gourmet and the Perfume of the Lady in Black by Bruno Podalydes.
In 2010 she directed her fourth feature film, No et Moi, based on the novel by Delphine De Vigan. In 2017 she co-wrote and directed the TV series Paris Etc. for Canal Plus.
She has also pursued a successful career as a theater director, notably Winter under the table (Molière du Metteur en Scène 2003) by Roland Topor, Des Gens, an adaptation of Molière’s work by Raymond Depardon and La Compagnie des spectres (2010) by Lydie Salvayre. Currently her show logiquimperturbabledufou is being performed at the Theater du Rond-Point, in Paris.